Key result
Theoretical modeling of oxygen diffusion in isolated cardiac muscle demonstrates that radius-dependent diminution of performance cannot be attributed entirely to insufficient oxygen supply.
Population
Isolated cardiac muscle preparations (papillary muscles or trabeculae carneae) modeled theoretically
Design
Preclinical
Authors
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Questions reliance on oxygen alone for size effects in isolated muscle; leaves open alternative mechanisms for experimental validation.
Theoretical modeling suggests that the radius-dependent decline in performance of isolated cardiac muscles in vitro is not solely due to inadequate oxygen diffusion.
Han et al. (2011) studied Cardiac energetics in isolated muscle preparations. Theoretical modeling of oxygen diffusion was evaluated on Radius-dependent diminution of muscle performance. Theoretical modeling of oxygen diffusion in isolated cardiac muscle demonstrates that radius-dependent diminution of performance cannot be attributed entirely to insufficient oxygen supply.
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