Key result
Heat shock and adenovirus infection demonstrate that cap-dependent translation is independently regulated by the phosphorylation states of eIF-4E and the 4E-binding protein BP-1.
Population
animal cells
Design
Preclinical
Authors
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Hypothesis-generating in animal models; leaves open applicability to human cardiovascular conditions.
eIF-4E and BP-1 independently regulate cap-dependent translation, acting either in concert or in opposition depending on the cellular stress or infection.
FEIGENBLUM et al. (1996) studied Cap-dependent translation regulation. Heat shock, adenovirus infection, and rapamycin was evaluated on Phosphorylation states of eIF-4E and BP-1 and cap-dependent translation. Heat shock and adenovirus infection demonstrate that cap-dependent translation is independently regulated by the phosphorylation states of eIF-4E and the 4E-binding protein BP-1.
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