Key result
The NOS 1 inhibitor VNIO inhibited approximately 40% of NOS activity in the mesenteric arterial bed of Sprague-Dawley rats, demonstrating the existence of functional NOS 1 in resistance arteries.
Why the study?
Does NOS 1 inhibition with VNIO alter phenylephrine contraction and NOS activity in isolated mesenteric resistance arteries from Sprague-Dawley rats?
Does NOS 1 inhibition with VNIO alter phenylephrine contraction and NOS activity in isolated mesenteric resistance arteries from Sprague-Dawley rats?
Functional NOS 1 exists in resistance arteries and modulates vascular tone, extending previous findings from large arteries.
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Hypothesis-generating for NOS1 in resistance vessels; leaves open any clinical role pending human data.
Sullivan et al. (2002) studied this question. N(5)-(1-imino-3-butenyl)-L-ornithine (VNIO) vs. Absence of VNIO was evaluated on NOS activity inhibition by VNIO in cytosolic and particulate fractions. The NOS 1 inhibitor VNIO inhibited approximately 40% of NOS activity in the mesenteric arterial bed of Sprague-Dawley rats, demonstrating the existence of functional NOS 1 in resistance arteries.
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