Key result
Long-term antihypertensive therapy achieved sustained blood pressure control, but 468 cardiovascular events occurred over 50,000 person-years, with incidence varying up to 14-fold by baseline risk.
Why the study?
What are the distribution and determinants of cardiovascular events in hypertensive patients undergoing long-term antihypertensive therapy?
Cohort (n=8,690)
No
What are the distribution and determinants of cardiovascular events in hypertensive patients undergoing long-term antihypertensive therapy?
Despite successful long-term blood pressure control, cardiovascular events remain the primary cause of morbidity and mortality, and baseline clinical profiles can effectively stratify this residual risk.
No takes yet. Share an insight, caveat, or question.
Residual cardiovascular events persist despite control; supports baseline risk stratification but leaves targeted interventions open.
Alderman et al. (1998) conducted a cohort in Hypertension (n=8,690). Antihypertensive therapy was evaluated on Blood pressure and incidence of morbid and mortal cardiovascular events. Long-term antihypertensive therapy achieved sustained blood pressure control, but 468 cardiovascular events occurred over 50,000 person-years, with incidence varying up to 14-fold by baseline risk.
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