Key result
Long-term antihypertensive therapy achieved sustained blood pressure control, but 468 cardiovascular events occurred over 50,000 person-years, with incidence varying up to 14-fold by baseline risk.
Why the study?
What are the distribution and determinants of cardiovascular events in hypertensive patients undergoing long-term antihypertensive therapy?
Population
8,690 systematically treated hypertensive patients in a worksite-based program in New York City.
Design
Cohort
Follow-up
average of 5.7 years
Authors
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Residual cardiovascular events persist despite control; supports baseline risk stratification but leaves targeted interventions open.
Cohort (n=8,690)
No
What are the distribution and determinants of cardiovascular events in hypertensive patients undergoing long-term antihypertensive therapy?
Despite successful long-term blood pressure control, cardiovascular events remain the primary cause of morbidity and mortality, and baseline clinical profiles can effectively stratify this residual risk.
Alderman et al. (1998) conducted a cohort in Hypertension (n=8,690). Antihypertensive therapy was evaluated on Blood pressure and incidence of morbid and mortal cardiovascular events. Long-term antihypertensive therapy achieved sustained blood pressure control, but 468 cardiovascular events occurred over 50,000 person-years, with incidence varying up to 14-fold by baseline risk.
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