Key result
Truncation of either the amino or carboxyl terminus of c-Myb is sufficient for transformation of chicken bone marrow cells, whereas overexpression of full-length c-Myb is not.
Population
Chicken bone marrow cells
Comparison
Avian retroviruses expressing full-length or… vs Overexpression of full-length c-Myb and v-Myb
Design
Preclinical
Authors
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No immediate clinical implications from avian cells; leaves open c-Myb truncation's role in human leukemogenesis.
Protein truncation at either the amino or carboxyl terminus is required and sufficient for the activation and transforming ability of the c-Myb proto-oncogene.
Grässer et al. (1991) studied Oncogenesis. Truncated forms of c-Myb vs. Full-length c-Myb was evaluated on Transformation of chicken bone marrow cells. Truncation of either the amino or carboxyl terminus of c-Myb is sufficient for transformation of chicken bone marrow cells, whereas overexpression of full-length c-Myb is not.
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