July 1, 1986Proceedings of the National Academy of SciencesOpen Access

Antibodies to the evolutionarily conserved amino-terminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species.

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Structured PICO

Population

Various metazoan species (avian, human, murine, Drosophila) and immature cells of the erythroid, myeloid, and lymphoid lineages

Intervention

Antibodies directed against a bacterial fusion protein containing the domain encoded by the highly evolutionarily conserved 5' one-third of the v-myb oncogene of avian myeloblastosis virus (AMV)

Outcome

Detection of protein products of various members of the myb gene family via immunoprecipitation or immunoblot analysessurrogate

Antibodies against the conserved amino-terminal region of v-myb can detect c-myb proteins across widely divergent metazoan species, demonstrating high evolutionary conservation of this protein domain.

Discussion

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Implication

May aid cross-species myb protein studies in models; leaves open any cardiovascular relevance or clinical translation.

Cite This Study

Boyle et al. (1986) studied this question.

synapsesocial.com/papers/6a707aa6a7fbea1e440817df https://doi.org/10.1073/pnas.83.13.4685

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Antibodies to the evolutionarily conserved amino-terminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species.

Structured PICO

Discussion

Implication

Cite This Study

Antibodies to the evolutionarily conserved amino-terminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider