Key result
Poliovirus infection induces intracellular alkalinization in HeLa cells via activation of a vacuolar-type proton ATPase, likely involving protein kinase C-mediated phosphorylation.
Population
HeLa cells
Comparison
Poliovirus infection vs Control monolayer cultures
Design
Preclinical
Follow-up
2 hours postinfection
Authors
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Hypothesis-generating in cell models; leaves open in vivo relevance and therapeutic translation.
Poliovirus infection induces intracellular alkalinization in HeLa cells through the activation of a vacuolar-type proton ATPase, likely mediated by protein kinase C phosphorylation.
Holsey et al. (1993) studied Poliovirus infection. Poliovirus infection vs. Control monolayer cultures or UV-inactivated virus was evaluated on Changes in intracellular pH (pHi). Poliovirus infection induces intracellular alkalinization in HeLa cells via activation of a vacuolar-type proton ATPase, likely involving protein kinase C-mediated phosphorylation.
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