Population
HeLa cells infected with poliovirus
Comparison
Lysosomotropic amines vs Untreated cells
Design
Preclinical
Authors
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Challenges pH-dependent uncoating models for poliovirus; leaves open mechanistic validation and antiviral implications in vivo.
Poliovirus uncoating in HeLa cells appears to occur via a mechanism that is independent of low pH in endosomal compartments.
Gromeier et al. (1990) studied this question.
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