February 27, 2001Biochemistry

Entry of Poliovirus into Cells Is Blocked by Valinomycin and Concanamycin A

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Structured PICO

Population

Susceptible cells (in vitro model for poliovirus infection)

Intervention

Combination of concanamycin A (a vacuolar proton-ATPase inhibitor) and valinomycin (an ionophore that promotes K+ efflux), or modifying ionic conditions (increasing K+ and decreasing Na+) together with concanamycin A

Outcome

Productive entry of poliovirus into cells (measured by viral protein synthesis and eIF4G-1 cleavage mediated by poliovirus protease 2A)surrogate

The combination of concanamycin A and valinomycin, or modifying extracellular K+/Na+ ratios, prevents poliovirus entry, suggesting viral uncoating requires an intact intracellular K+ concentration.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not change clinical practice for poliovirus; leaves open ionic modulation as antiviral target.

Cite This Study

Irurzun et al. (2001) studied this question.

synapsesocial.com/papers/6a8d062f79634a65278e4e07 https://doi.org/10.1021/bi002069p

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Entry of Poliovirus into Cells Is Blocked by Valinomycin and Concanamycin A

Structured PICO

Discussion

Implication

Cite This Study

Entry of Poliovirus into Cells Is Blocked by Valinomycin and Concanamycin A

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider