Population
HeLa cells and Vero cells infected with poliovirus (and vesicular stomatitis virus or influenza virus)
Comparison
Monensin or nigericin added after poliovirus entry vs Untreated poliovirus-infected cells
Design
Preclinical
Follow-up
up to 8 hours post-infection
Authors
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Ionophores merit antiviral exploration; animal data leaves open human translation for poliovirus.
Monensin and nigericin inhibit poliovirus genome replication and prevent host translation shutoff despite p220 cleavage, suggesting ongoing cellular protein synthesis does not require intact p220.
Irurzun et al. (1995) studied this question.
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