Why the study?
Does poliovirus infection alter membrane functions in HeLa cells?
Population
HeLa cells
Comparison
Poliovirus infection vs Control HeLa cells
Design
Preclinical
Follow-up
3 hours post-infection
Authors
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Early membrane disruption in poliovirus-infected cells supports shutoff mechanisms; leaves open relevance to human enteroviral disease.
Does poliovirus infection alter membrane functions in HeLa cells?
Poliovirus infection induces significant alterations in HeLa cell membrane functions, supporting the hypothesis that membrane modification is key to viral shutoff of host metabolism.
Schaefer et al. (1982) studied this question.
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