Poliovirus infection rapidly alters plasma-membrane functions in HeLa cells, including changes in ATPase activity and cell volume.
Early membrane changes after poliovirus infection may guide antiviral research; leaves open mechanistic and therapeutic relevance in vivo.
After exposure of HeLa cells to poliovirus there is a rapid decline (within minutes) in fluorescence polarization of DPH (1,6-diphenyl-1,3,5-hexatriene). Within one hour after infection the (Na+/K+)ATPase activity of an isolated plasma-membrane-rich fraction is enhanced, the cell volume decreases, and the intracellular concentration of a potent low-molecular-weight inhibitor of host protein synthesis increases.
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Schaefer et al. (1982) studied this question.
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