Population
HeLa cells grown in monolayer infected with poliovirus
Comparison
2 mM guanidine added at the time of infection or… vs Uninfected HeLa cells or infected cells without…
Design
Preclinical
Authors
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Highlights necessity of viral protein synthesis for poliovirus membrane alterations; leaves open in vivo relevance and therapeutic translation.
Viral protein synthesis is necessary for the modification of membrane permeability and potential in poliovirus-infected HeLa cells, which can be prevented by early addition of guanidine or cycloheximide.
Lacal et al. (1983) studied this question.
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