Key result
Endothelin-1 plays a complex role in coronary artery disease and myocardial infarction, and clinical studies examining endothelin receptor blockade have yielded largely contradictory results.
Population
Patients with coronary artery disease, myocardial infarction, and chronic heart failure
Design
Review
Authors
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Endothelin receptor blockade lacks consistent benefit in CAD/MI; leaves open targeted trials in defined phenotypes.
Endothelin-1 plays a complex role in CAD and MI, but clinical trials of endothelin receptor blockade have yielded contradictory results.
Kolettis et al. (2013) conducted a review in Coronary Artery Disease and Myocardial Infarction. Endothelin receptor blockade was evaluated. Endothelin-1 plays a complex role in coronary artery disease and myocardial infarction, and clinical studies examining endothelin receptor blockade have yielded largely contradictory results.
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