Key result
Non-obstructive HCM with preserved systolic function had the most accelerated progression to advanced heart failure and adverse outcomes compared with other HCM profiles (P=0.04).
Cohort (n=293)
Advanced heart failure in HCM presents in three distinct profiles, with atrial fibrillation being a major contributor and non-obstructive preserved systolic function showing the most rapid progression.
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May warrant closer surveillance in non-obstructive HCM; leaves open whether early intervention alters progression.
Melacini et al. (2010) conducted a cohort in Hypertrophic cardiomyopathy (n=293). Non-obstructive HCM with preserved systolic function had the most accelerated progression to advanced heart failure and adverse outcomes compared with other HCM profiles (P=0.04).
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