Key result
Heart failure presentation at diagnosis in hypertrophic cardiomyopathy patients independently predicted death or heart transplant (HR 2.59; 95% CI 1.09-6.17; P=0.032).
Why the study?
Does clinical presentation at diagnosis predict death or heart transplant in symptomatic patients with hypertrophic cardiomyopathy?
Cohort (n=84)
Does clinical presentation at diagnosis predict death or heart transplant in symptomatic patients with hypertrophic cardiomyopathy?
Effect estimate: HR 2.59 (95% CI 1.09-6.17)
p-value: p=0.032
In symptomatic patients with hypertrophic cardiomyopathy, presentation with heart failure is associated with a significantly higher risk of death or heart transplant compared to presentation with syncope, palpitations, or chest pain.
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Heart failure presentation at hypertrophic cardiomyopathy diagnosis may identify higher-risk patients; extends risk stratification but leaves open prospective validation.
Finocchiaro et al. (2012) conducted a cohort in Hypertrophic cardiomyopathy (n=84). Heart failure presentation vs. Other symptoms (syncope/palpitations or chest pain) was evaluated on Death or heart transplant (HR 2.59, 95% CI 1.09-6.17, p=0.032). Heart failure presentation at diagnosis in hypertrophic cardiomyopathy patients independently predicted death or heart transplant (HR 2.59; 95% CI 1.09-6.17; P=0.032).
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