Why the study?
Although implantable cardioverter-defibrillators are standard treatment, additional antiarrhythmic drugs may be needed to prevent recurrent ventricular fibrillation episodes or electrical storms associated with inferolateral early repolarization.
Do specific antiarrhythmic drugs prevent recurrent ventricular fibrillation in patients with idiopathic VF and inferolateral early repolarization?
Population
122 patients with idiopathic VF and inferolateral early repolarization abnormality
Comparison
Physician-selected antiarrhythmic drugs for recurrent VF or electrical storms
Design
Multicenter cohort study
Follow-up
69 +/- 58 months
Key result
Isoproterenol suppressed electrical storms in 7 of 7 acute cases, and quinidine eliminated recurrent VF in 9 of 9 chronic cases, whereas other antiarrhythmic drugs were poorly effective.
Authors
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May guide therapy in refractory early repolarization VF; hypothesis-generating and requires randomized confirmation.
Cohort (n=122)
Yes
Do specific antiarrhythmic drugs prevent recurrent ventricular fibrillation in patients with idiopathic VF and inferolateral early repolarization?
Isoproterenol and quinidine are highly effective for the acute and chronic suppression, respectively, of recurrent ventricular fibrillation in patients with inferolateral early repolarization.
Haı̈ssaguerre et al. (2009) conducted a cohort in Idiopathic ventricular fibrillation with inferolateral early repolarization (n=122). Antiarrhythmic drugs (isoproterenol, quinidine) was evaluated on Elimination of all recurrences of VF with a minimal follow-up period of 12 months. Isoproterenol suppressed electrical storms in 7 of 7 acute cases, and quinidine eliminated recurrent VF in 9 of 9 chronic cases, whereas other antiarrhythmic drugs were poorly effective.
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