Key result
Left stellate ganglion block in dogs with heart failure caused only small reductions in cardiac output (2.8 vs 2.7 L/min, P=0.04) and left ventricular pressure (119 vs 112 mm Hg, P=0.01).
Why the study?
Does left stellate ganglion block affect left ventricular function in awake dogs before and after induction of heart failure?
Does left stellate ganglion block affect left ventricular function in awake dogs before and after induction of heart failure?
Left stellate ganglion block produces only small hemodynamic changes in awake dogs even during heart failure, suggesting a broad margin of safety.
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Indicates safety margin for stellate ganglion block in failing hearts; leaves open human translation.
Müllenheim et al. (2000) studied Pacing-induced congestive heart failure (n=12). Left stellate ganglion block (LSGB) vs. Baseline/Control was evaluated on Global hemodynamics (cardiac output, left ventricular pressure, dP/dt) and regional myocardial function. Left stellate ganglion block in dogs with heart failure caused only small reductions in cardiac output (2.8 vs 2.7 L/min, P=0.04) and left ventricular pressure (119 vs 112 mm Hg, P=0.01).
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