Key result
Enoximone administration in newborns with refractory postoperative low-output states increased cardiac index by 160% (P<0.0008) and resulted in haemodynamic improvement in 75% of patients.
Why the study?
Does enoximone improve haemodynamics and survival in newborns with postoperative, catecholamine-refractory cardiac low-output states?
Observational (n=16)
Does enoximone improve haemodynamics and survival in newborns with postoperative, catecholamine-refractory cardiac low-output states?
Enoximone improves haemodynamic parameters and may be an effective adjunctive therapy in neonates with postoperative cardiac low-output states refractory to high-dose catecholamines.
Answers are grounded in this paper and cite their sources.
May support adjunctive enoximone in refractory neonatal low-output states; hypothesis-generating and requires prospective trials before practice change.
Enoximone was administered to 16 newborns with postoperative, catecholamine-refractory cardiac low-output states in addition to high-dose catecholamine treatment. Haemodynamic changes were assessed at baseline and during treatment. Haemodynamic parameters were improved in 12 newborns ("responders"), 9 of these survived. Three responders died; one from cardiac low-output and 2 from uncorrectable congenital heart disease verified by autopsy. Four newborns did not respond to enoximone therapy ("non-responders") and died. The haemodynamic effects of enoximone were characterized by an increase in cardiac index (+160%, P less than 0.0008), and a fall in right (-26%, P less than 0.0004) and left (-34%, P less than 0.003) atrial pressures. It is concluded that enoximone can be an effective agent in the treatment of cardiac low-output states refractory to high-dose catecholamines in neonates up to 7 months old.
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Hausdorf et al. (1992) conducted an observational in postoperative, catecholamine-refractory cardiac low-output states (n=16). Enoximone vs. Baseline was evaluated on Change in cardiac index (p=<0.0008). Enoximone administration in newborns with refractory postoperative low-output states increased cardiac index by 160% (P<0.0008) and resulted in haemodynamic improvement in 75% of patients.
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