Key result
Insulin resistance was associated with decreased subcutaneous adipose tissue expression of FOXC2 and brown adipogenic genes compared to insulin-sensitive subjects.
Population
Adult human subjects with insulin resistance and insulin-sensitive subjects
Design
Cross-sectional
Authors
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Supports link between reduced adipose browning and insulin resistance; hypothesis-generating and requires prospective studies before clinical relevance.
Observational
A reduced brown adipose phenotype, indicated by decreased expression of FOXC2 and brown adipogenic genes, is associated with insulin resistance in humans.
Yang et al. (2003) conducted an observational in Insulin resistance. Insulin resistance vs. Insulin sensitivity was evaluated on Subcutaneous adipose tissue expression of FOXC2 and brown adipogenic genes. Insulin resistance was associated with decreased subcutaneous adipose tissue expression of FOXC2 and brown adipogenic genes compared to insulin-sensitive subjects.
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