Key result
The proBNP-108/total BNP ratio was significantly higher in heart failure patients with ventricular overload compared to those with atrial overload (0.45 vs 0.20, p<0.001).
Why the study?
How do the levels and ratios of BNP-32 and proBNP-108 differ among normal individuals, patients with atrial fibrillation, and patients with heart failure?
Observational (n=160)
How do the levels and ratios of BNP-32 and proBNP-108 differ among normal individuals, patients with atrial fibrillation, and patients with heart failure?
Absolute Event Rate: 0.45% vs 0.2%
p-value: p=<0.001
The ratio of proBNP-108 to total BNP varies by pathophysiological state, increasing in association with ventricular overload in heart failure.
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Ratio differences support distinct BNP processing by overload type in HF; leaves open diagnostic or prognostic utility.
Nishikimi et al. (2009) conducted an observational in Heart failure and atrial fibrillation (n=160). Measurement of plasma BNP-32 and proBNP-108 vs. Normal individuals and atrial fibrillation patients was evaluated on proBNP-108/total BNP ratio in heart failure with ventricular versus atrial overload (p=<0.001). The proBNP-108/total BNP ratio was significantly higher in heart failure patients with ventricular overload compared to those with atrial overload (0.45 vs 0.20, p<0.001).
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