Key result
Human brain myelin, neurons, and oligodendroglia contained 2.0, 1.3, and 0.35 μg ganglioside sialic acid per mg protein, respectively, with GM4 specifically localized in myelin and oligodendroglia.
This study identifies GM4 as a specific marker for human myelin and oligodendroglial perikarya in the central nervous system.
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GM4 localization suggests myelin specificity in human CNS; leaves open its utility as biomarker pending validation.
Yu et al. (1979) studied this question. Human brain myelin, neurons, and oligodendroglia contained 2.0, 1.3, and 0.35 μg ganglioside sialic acid per mg protein, respectively, with GM4 specifically localized in myelin and oligodendroglia.
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