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September 1, 1978Journal of Lipid ResearchOpen Access

Gangliosides of human, cat, and rabbit spinal cords and cord myelin.

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Population

Human, cat, and rabbit whole spinal cords and cord myelin

Comparison

Isolation and analysis of gangliosides using a… vs Cerebral gray matter, cerebral white matter, and…

Design

Preclinical

Authors

KUK. UenoOmuta hospitalSAS AndoYale UniversityRYRobert K. YuCarle Foundation Hospital

Discussion

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Implication

Human spinal cord myelin ganglioside patterns differ from brain across species; extends comparative neurochemistry but leaves open functional or clinical roles.

Structured PICO

P
Population
Human, cat, and rabbit whole spinal cords and cord myelin
I
Intervention
Isolation and analysis of gangliosides using a revised methodology (DEAE-Sephadex column chromatography, base treatment, Sephadex G-50 column chromatography, and Iatrobeads column chromatography)
C
Comparator
Cerebral gray matter, cerebral white matter, and cerebral white matter myelin
O
Outcome
Ganglioside concentration and patternsurrogate

The study identifies unique ganglioside patterns in the spinal cords and cord myelin of humans, cats, and rabbits compared to cerebral tissues, highlighting species-specific differences such as the enrichment of Gm4 in human myelin.

Cite This Study

Ueno et al. (1978) studied this question.

synapsesocial.com/papers/6a8a759b39266fd5f3ec6209https://doi.org/10.1016/s0022-2275(20)40700-x
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Also Consider

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  2. 2STUDIES OF THE MECHANISM OF DEMYELINATION REGIONAL DIFFERENCES IN MYELIN STABILITY IN VITRO1975 · 42 citations
  3. 3BIPHASIC MYELINATION AND THE FATTY ACID COMPOSITION OF CEREBROSIDES AND CHOLESTEROL ESTERS IN THE DEVELOPING CENTRAL NERVOUS SYSTEM OF THE DOMESTIC PIG1976 · 50 citations
  4. 4CHANGES IN THE SCIATIC NERVE OF THE RABBIT AND ITS TISSUE CONSTITUENTS DURING DEVELOPMENT<sup>1</sup>1974 · 44 citations