Key result
Molecular methodologies provide insight into the pathogenesis of sarcomas and influence the clinical management, diagnosis, prognosis, and determination of therapeutic targets for these tumors.
Discusses the applications of molecular methodologies in the diagnosis, prognosis, and clinical management of sarcomas.
May guide sarcoma diagnosis and targeted therapy; leaves open prospective validation before routine use.
Sarcomas are rare malignancies of mesenchymal lineage with more than 100 specific types and many benign potential mimics. In situ and precursor lesions are generally not described and thus much of molecular pathology in this field concentrates on molecular diagnosis, prognosis and determination of therapeutic targets. This chapter discusses the applications of molecular methodologies that provide insight into pathogenesis of sarcoma, and of molecular methods which are currently applied to, or will likely soon influence, the clinical management of this complex array of tumors.
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Powers et al. (2011) conducted a review in Sarcomas. Molecular methodologies was evaluated. Molecular methodologies provide insight into the pathogenesis of sarcomas and influence the clinical management, diagnosis, prognosis, and determination of therapeutic targets for these tumors.
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