Key result
Mechanical elongation of smooth muscle cells to approximately 120% of slack length induces ryanodine receptor-mediated Ca(2+) release in individual myocytes.
Longitudinal stretch of smooth muscle cells induces calcium release through ryanodine receptor gating, providing a mechanism for physiological responses to increased luminal pressure.
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May inform vascular mechanotransduction; hypothesis-generating in animal models and requires in vivo validation before clinical relevance.
Ji et al. (2002) studied Smooth muscle physiology. Mechanical elongation (stretch) was evaluated on Ca(2+) release from intracellular stores. Mechanical elongation of smooth muscle cells to approximately 120% of slack length induces ryanodine receptor-mediated Ca(2+) release in individual myocytes.
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