Younger B-cell non-Hodgkin's lymphoma survivors had higher relative risks than older survivors for specific cardiovascular diseases, including chronic rheumatic disease of the heart valves (HR 4.14).
Cohort
Does younger age at diagnosis increase the relative risk of cardiovascular disease in B-cell non-Hodgkin's lymphoma survivors compared to older survivors and the general population?
Younger survivors of B-cell non-Hodgkin's lymphoma face a disproportionately higher relative risk of developing specific cardiovascular diseases compared to older survivors and the general population.
Effect estimate: HR 4.14 (95% CI 2.17-7.89)
p-value: p=0.004
Abstract Introduction Young cancer survivors may be at increased risk of early‐onset chronic health conditions. The aim of this population‐based study is to estimate cardiovascular disease (CVD) risk among younger versus older B‐cell non‐Hodgkin's lymphoma (B‐NHL) survivors compared with their respective general population cohorts. Methods B‐NHL survivors diagnosed from 1997 to 2015 in the Utah Cancer Registry were matched with up to five cancer‐free individuals on birth year, sex, and birth state, using the statewide Utah Population Database. Electronic medical records and statewide health care facility data were used to identify disease outcomes ≥5 years after cancer diagnosis. Cox Proportional Hazards models were used to estimate hazard ratios for B‐NHL survivors diagnosed at <65 years and ≥65 years old. Results Younger B‐NHL survivors had higher relative risks than older cancer survivors of chronic rheumatic disease of the heart valves (HR = 4.14, 99% CI = 2.17–7.89; P value heterogeneity = 0.004); peri‐, endo‐, and myocarditis (HR = 2.43, 99% CI = 1.38–4.28; P value heterogeneity = 0.016); diseases of the arteries (HR = 1.63, 99% CI = 1.21–2.21; P value heterogeneity = 0.044); and hypotension (HR = 2.44, 99% CI = 1.58–3.75; P value heterogeneity = 0.048). B‐NHL survivors of both age groups had elevated relative risks of heart disease overall and congestive heart failure. Conclusion Younger B‐NHL survivors had higher risks than older B‐NHL survivors of specific cardiovascular diseases compared to their respective general population cohorts.
Ocier et al. (Wed,) conducted a cohort in B-cell non-Hodgkin's lymphoma survivors. B-NHL survivorship (younger vs older) vs. Cancer-free individuals was evaluated on Cardiovascular disease risk (chronic rheumatic disease of the heart valves) (HR 4.14, 95% CI 2.17-7.89, p=0.004). Younger B-cell non-Hodgkin's lymphoma survivors had higher relative risks than older survivors for specific cardiovascular diseases, including chronic rheumatic disease of the heart valves (HR 4.14).