Key result
Oral quinapril for 20 weeks significantly reduced interstitial collagen volume fraction in spontaneously hypertensive rats compared to untreated controls (3.42% vs 5.73%, P<0.05).
Why the study?
Does quinapril reduce interstitial fibrosis and extracellular matrix accumulation in spontaneously hypertensive rats with left ventricular hypertrophy?
Does quinapril reduce interstitial fibrosis and extracellular matrix accumulation in spontaneously hypertensive rats with left ventricular hypertrophy?
Absolute Event Rate: 3.42% vs 5.73%
p-value: p=< .05
Quinapril reverses interstitial fibrosis and adverse structural remodeling of the cardiac interstitium in a rat model of hypertensive left ventricular hypertrophy.
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Supports quinapril reducing fibrosis in hypertensive rat LVH; hypothesis-generating and leaves open human translation.
Panizo et al. (1995) studied Hypertension with left ventricular hypertrophy. Quinapril vs. Untreated SHR and Wistar-Kyoto (WKY) controls was evaluated on Interstitial collagen volume fraction (p=< .05). Oral quinapril for 20 weeks significantly reduced interstitial collagen volume fraction in spontaneously hypertensive rats compared to untreated controls (3.42% vs 5.73%, P<0.05).
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