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October 1, 1995Journal of Hypertension

Are mast cells involved in hypertensive heart disease?

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Key result

Quinapril treatment in spontaneously hypertensive rats markedly decreased myocardial fibrosis, collagen volume fraction, and mast cell count compared to untreated rats.

Why the study?

Does quinapril reduce mast cell density and myocardial fibrosis in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats with established left ventricular hypertrophy and normotensive Wistar-Kyoto…

Comparison

Oral quinapril for 20 weeks vs Untreated spontaneously hypertensive rats and…

Design

Preclinical

Follow-up

20 weeks

Authors

ÁPÁngel PanizoMemorial Sloan Kettering Cancer CenterFMF. J. Pardo MindanClinica Universidad de NavarraMGMarı́a F. GalindoInstituto Tecnico Agronómico Provincial

Discussion

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Implication

May implicate mast cells in hypertensive fibrosis; leaves open quinapril translation to patients.

Structured PICO

Does quinapril reduce mast cell density and myocardial fibrosis in spontaneously hypertensive rats?

P
Population
Spontaneously hypertensive rats (SHR) with established left ventricular hypertrophy (n=12 untreated, n=12 treated) and normotensive Wistar-Kyoto (WKY) rats (n=12). Total n=36.
I
Intervention
Oral quinapril (10 mg/kg body weight per day) for 20 weeks
C
Comparator
Untreated spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
O
Outcome
Myocardial fibrosis (collagen volume fraction, hydroxyproline concentration) and mast cell densitysurrogate

Mast cells may play a role in the development of hypertensive myocardial fibrosis, and the cardioreparative properties of quinapril may involve interference with mast cells.

Cite This Study

Panizo et al. (1995) studied Hypertensive heart disease (n=36). Quinapril vs. Untreated spontaneously hypertensive rats and normotensive Wistar-Kyoto rats was evaluated on Myocardial fibrosis and mast cell density. Quinapril treatment in spontaneously hypertensive rats markedly decreased myocardial fibrosis, collagen volume fraction, and mast cell count compared to untreated rats.

synapsesocial.com/papers/6a11c63635a4eec8fedcd05bhttps://doi.org/10.1097/00004872-199510000-00015

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy.1991 · 326 citations
  2. 2Long-term pressure-induced cardiac hypertrophy: capillary and mast cell proliferation1989 · 62 citations
  3. 3Prolonged Inhibition of Local Angiotensin-Converting Enzyme After Single or Repeated Treatment with Quinapril in Spontaneously Hypertensive Rats1992 · 35 citations
  4. 4Structural remodeling in hypertensive heart disease and the role of hormones.1994 · 232 citations
  5. 5Angiotensin converting enzyme inhibition prevents the increase in aortic collagen in rats.1994 · 139 citations