Key result
Early inhibition of AT1 receptors with A-81988 attenuated hypertension development in spontaneously hypertensive rats (systolic BP 136 vs 185 mmHg, P<0.01), but did not prevent its heritability.
Why the study?
Does A-81988 prevent the development of genetic hypertension and its heritability in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and their progeny
Comparison
A-81988 administered in drinking water from… vs Tap water
Design
Preclinical
Follow-up
Up to 21 weeks of age (14 weeks on treatment, 7 weeks off)
Authors
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May limit hypertension progression in genetic rat models; leaves open effects on heritability and human translation.
Does A-81988 prevent the development of genetic hypertension and its heritability in spontaneously hypertensive rats?
Absolute Event Rate: 136% vs 185%
p-value: p=< 0.01
Pharmacological blockade of AT1 receptors attenuates the development of hypertension in spontaneously hypertensive rats but does not alter the genetic heritability of the hypertensive trait.
Madeddu et al. (1995) studied Hypertension. A-81988 vs. Tap water was evaluated on Systolic blood pressure at 14 weeks (p=< 0.01). Early inhibition of AT1 receptors with A-81988 attenuated hypertension development in spontaneously hypertensive rats (systolic BP 136 vs 185 mmHg, P<0.01), but did not prevent its heritability.
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