Key result
Early AT1 receptor blockade with SR/BMS in spontaneously hypertensive rats limited genetic hypertension development and cardiovascular remodeling during treatment and persistently after withdrawal.
Why the study?
Does early AT1 receptor blockade with SR 47436/BMS-186295 limit genetic hypertension development and cardiovascular remodeling in spontaneously hypertensive rats?
Population
Young spontaneously hypertensive rats (SHR)
Comparison
SR 47436/BMS-186295 60 mg/kg per day, orally… vs Distilled water
Design
Preclinical
Follow-up
Up to 28 weeks of age (8 weeks after treatment withdrawal)
Authors
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Preclinical data do not change practice; leaves open whether early AT1 blockade alters human genetic hypertension trajectories.
Does early AT1 receptor blockade with SR 47436/BMS-186295 limit genetic hypertension development and cardiovascular remodeling in spontaneously hypertensive rats?
Early AT1 receptor blockade in spontaneously hypertensive rats prevents the development of genetic hypertension and cardiovascular remodeling, with effects persisting even after treatment withdrawal.
Vacher et al. (1995) studied genetic hypertension. SR 47436/BMS-186295 (SR/BMS) vs. distilled water was evaluated on systemic and regional haemodynamic and cardiac and vascular morphological parameters. Early AT1 receptor blockade with SR/BMS in spontaneously hypertensive rats limited genetic hypertension development and cardiovascular remodeling during treatment and persistently after withdrawal.
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