Key result
Histological study of six 'fresh' human aortic valve allografts functioning for 14 to 442 weeks showed a gradual replacement fibrosis of the graft by the host at varying rates.
Observational (n=6)
Fresh human aortic valve allografts undergo gradual replacement fibrosis by host tissue at varying rates over time.
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Should not yet change allograft practices; hypothesis-generating for host-graft durability in larger cohorts.
Gavin et al. (1973) conducted an observational in Aortic valve replacement (n=6). 'Fresh' human aortic valve allografts was evaluated on Histopathological changes in the allografts. Histological study of six 'fresh' human aortic valve allografts functioning for 14 to 442 weeks showed a gradual replacement fibrosis of the graft by the host at varying rates.