Key result
Histologic examination of 9 explanted cryopreserved allograft aortic valves showed variable cellularity, with persistence of donor cells demonstrated in one valve at 9.2 years post-implantation.
Why the study?
Do viable cryopreserved allograft aortic valves retain donor cell viability and persistence after implantation?
Population
9 explanted viable cryopreserved allograft aortic valves from a cohort of 231 patients who underwent aortic…
Design
Case_series
Follow-up
2 months to 10.8 years
Authors
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Viable cryopreserved allografts show sustained durability after AVR; leaves open randomized comparisons to modern prostheses.
Observational (n=231)
Do viable cryopreserved allograft aortic valves retain donor cell viability and persistence after implantation?
Donor cells can persist in viable cryopreserved allograft aortic valves for up to 9.2 years after implantation.
O’Brien et al. (1988) conducted an observational in Aortic valve replacement (n=231). Viable cryopreserved allograft aortic valve was evaluated on Histologic examination and cellularity of explanted valves. Histologic examination of 9 explanted cryopreserved allograft aortic valves showed variable cellularity, with persistence of donor cells demonstrated in one valve at 9.2 years post-implantation.
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