Why the study?
Does genetic predisposition to hypertension influence plasma and kidney renin activities in rats under various experimental regimens?
Does genetic predisposition to hypertension influence plasma and kidney renin activities in rats under various experimental regimens?
Genetic predisposition to hypertension significantly modifies plasma and kidney renin activities in rats independently of NaCl intake or renal artery constriction.
Answers are grounded in this paper and cite their sources.
Should not yet change clinical practice; leaves open genetic renin mechanisms in human hypertension.
Two strains of rats with opposite, genetically determined predispositions to hypertension were compared. Rats from the hypertension-prone strain had significantly lower plasma and kidney renin activities than did rats from the hypertension-resistant strain. Although renin activities were modified by NaCl intake and blood pressure, significant differences between the two strains were present with all four experimental regimens used: low-NaCl diet, high-NaCl diet, unilateral renal artery constriction, and unilateral renal artery constriction plus contralateral nephrectomy. Therefore, we concluded that renin activities along with blood pressure were modified by genetic influences in these two strains of rats.
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Iwai et al. (1973) studied Hypertension. Hypertension-prone strain vs. Hypertension-resistant strain was evaluated on Plasma and kidney renin activities.
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