Key result
Platelet lipoxygenase deficiency in patients with myeloproliferative disorders was associated with a significantly higher rate of bleeding complications compared to normal activity (67% vs 19%, P<0.001).
Why the study?
Does platelet lipoxygenase deficiency correlate with bleeding and thrombotic complications in patients with myeloproliferative disorders?
Population
60 patients with myeloproliferative disorders, and an unspecified number of patients with secondary…
Comparison
Presence of platelet lipoxygenase deficiency vs Normal platelet lipoxygenase activity
Design
Cross-sectional
Authors
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May support bleeding risk assessment in myeloproliferative disorders; leaves open causal role and distinction from secondary thrombocytosis.
Observational (n=60)
Does platelet lipoxygenase deficiency correlate with bleeding and thrombotic complications in patients with myeloproliferative disorders?
Absolute Event Rate: 67% vs 19%
p-value: p=<0.001
Platelet lipoxygenase deficiency in myeloproliferative disorders is significantly associated with increased bleeding complications and may help distinguish these disorders from secondary thrombocytosis or polycythemia.
Andrew I. Schafer (1982) conducted an observational in Myeloproliferative disorders (n=60). Platelet lipoxygenase deficiency vs. Normal lipoxygenase activity was evaluated on Bleeding complications (p=<0.001). Platelet lipoxygenase deficiency in patients with myeloproliferative disorders was associated with a significantly higher rate of bleeding complications compared to normal activity (67% vs 19%, P<0.001).
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