October 12, 1970JAMA
Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study
Key result
Asymptomatic hypertension was associated with an approximately four-fold increased risk of atherothrombotic brain infarction compared to normotension across all ages and both sexes.
Why the study?
Does hypertension increase the risk of atherothrombotic brain infarction in the general population?
Population
Framingham study cohort
Comparison
Hypertension (systolic or diastolic) vs Normotension
Design
Cohort
Authors
Discussion
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Member takes
Implication
Supports BP monitoring in asymptomatic adults; leaves open optimal intervention thresholds for stroke prevention.
Study Design
Type
Cohort
Structured PICO
Does hypertension increase the risk of atherothrombotic brain infarction in the general population?
P
Population
Framingham study cohort
I
Intervention
Hypertension (systolic or diastolic)
C
Comparator
Normotension
O
Outcome
Atherothrombotic brain infarction (ABI)hard clinical
Main Result
Effect estimate: 4-fold risk
Hypertension is a potent, direct precursor to atherothrombotic brain infarction, with systolic blood pressure being a strong predictor regardless of age or sex.
Cite This Study
William B. Kannel (1970) conducted a cohort in Hypertension and stroke. Hypertension vs. Normotension was evaluated on Atherothrombotic brain infarction (ABI) (4-fold risk). Asymptomatic hypertension was associated with an approximately four-fold increased risk of atherothrombotic brain infarction compared to normotension across all ages and both sexes.