Key result
Exercise paradoxically triggers a Brugada type 1 pattern despite typical isoproterenol use for VT storm.
Why the study?
Conversion to the higher-risk Brugada syndrome type 1 pattern during exercise is unusual, as isoproterenol is typically used to treat ventricular tachycardia storm in Brugada syndrome.
Can exercise induce a Brugada syndrome type 1 ECG pattern?
Case Report
Can exercise induce a Brugada syndrome type 1 ECG pattern?
Exercise is an unusual trigger for the Brugada type 1 ECG pattern, contrasting with the typical use of beta-adrenergic stimulation (isoproterenol) to treat VT storm in these patients.
Exercise may unmask Brugada type 1 pattern; leaves open adrenergic modulation mechanisms in phenotypic expression.
Brugada syndrome (BrS) is an inherited disorder usually afflicting patients with otherwise structurally normal hearts. Many triggers have been identified that can result in the phenotypic expression of the higher-risk BrS type 1 pattern. These triggers include but are not limited to fever, heightened vagal tone, and sodium (Na) channel blocking agents. Conversion to the type 1 pattern during exercise is unusual and in fact isoproterenol is a treatment for ventricular tachycardia (VT) storm in Brugada syndrome.
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Aboyme et al. (2022) conducted a case report in Brugada syndrome. Exercise was evaluated. Conversion to the Brugada syndrome type 1 pattern during exercise is an unusual phenotypic expression, contrasting with the typical use of isoproterenol to treat VT storm in these patients.
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