Key result
Evolut THV inflow stent expansion averages ~80% without compromising short-term valve hemodynamics.
Why the study?
In TAVI for bicuspid AS, concerns exist regarding reduced stent frame expansion and increased ellipticity, and the implications of these deformations on THV performance remain unclear.
Does stent frame deformation of the self-expanding Evolut THV impact valve performance in patients with bicuspid aortic stenosis?
Observational (n=175)
Yes
Does stent frame deformation of the self-expanding Evolut THV impact valve performance in patients with bicuspid aortic stenosis?
Absolute Event Rate: 79.9% vs 95.4%
p-value: p=<0.001
In patients with bicuspid aortic stenosis undergoing TAVI, stent frame under-expansion and ellipticity at the inflow level of the Evolut THV do not compromise short-term valve hemodynamics or cause leaflet thickening.
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Inflow under-expansion of Evolut THV was not associated with impaired short-term hemodynamics in bicuspid TAVI; leaves open questions on durability.
Tirado‐Conte et al. (2025) conducted an observational in bicuspid aortic stenosis (n=175). Evolut transcatheter heart valve was evaluated on Stent frame expansion at the inflow level compared to the leaflet level (p=<0.001). The Evolut THV had greater stent frame under-expansion at the inflow level than the leaflet level (79.9% vs 95.4%, P<0.001), but this did not compromise short-term valve hemodynamics.
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