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March 1, 1996Circulation

Reflex Control of Sympathetic Activity During Ventricular Tachycardia in Dogs

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Why the study?

What are the relative contributions of arterial and cardiopulmonary baroreflexes to the sympathetic and arterial pressure responses during ventricular tachycardia in dogs?

Population

12 dogs with a healed anteroapical infarction and inducible VT, and 8 control dogs (total n=20)

Comparison

Induced ventricular tachycardia or ventricular… vs Control dogs without infarction, and comparison…

Design

Preclinical

Authors

MSMichael L. SmithUniversity of North TexasTKToru KinugawaUniversity of RichmondMDMark E. Dibner‐DunlapUniversity Hospitals of Cleveland

Discussion

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Implication

Arterial baroreflexes may determine VT hemodynamics in dogs; leaves open translation to human arrhythmia care.

Structured PICO

What are the relative contributions of arterial and cardiopulmonary baroreflexes to the sympathetic and arterial pressure responses during ventricular tachycardia in dogs?

P
Population
12 dogs with a healed anteroapical infarction and inducible VT, and 8 control dogs (total n=20)
I
Intervention
Induced ventricular tachycardia (VT) or ventricular pacing (VP) at 220 to 280 beats per minute, evaluated with intact reflexes, selective denervation of arterial or cardiopulmonary baroreflexes, and combined denervation
C
Comparator
Control dogs without infarction, and comparison between intact and denervated reflex conditions
O
Outcome
Responses of renal sympathetic nerve activity (RSNA), pulmonary capillary wedge pressure (PCWP), and mean arterial pressure (MAP)surrogate

Arterial baroreflex-mediated sympathoexcitation is a primary determinant of hemodynamic outcomes during ventricular tachycardia, with cardiopulmonary baroreflexes playing a lesser modulatory role.

Cite This Study

Smith et al. (1996) studied this question.

synapsesocial.com/papers/6a0d2903d7cdc72b8665667ehttps://doi.org/10.1161/01.cir.93.5.1033

Topics

Ventricular arrhythmias
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impaired atrial receptor modulation or renal nerve activity in dogs with chronic volume overload11985 · 59 citations
  2. 2Selective impairment of baroreflex-mediated vasoconstrictor responses in patients with ventricular dysfunction.1984 · 258 citations
  3. 3Interruption of sympathetic and vagal-mediated afferent responses by transmural myocardial infarction.1985 · 112 citations
  4. 4Sustained ventricular tachycardia in recent canine myocardial infarction.1980 · 83 citations
  5. 5Renal sympathetic responses to conflicting baroreceptor inputs: rapid ventricular pacing in dogs.1993 · 12 citations