Key result
Patients with structural heart disease exhibited a wider diastolic interval range for APD alternans (68 vs 12 ms), earlier onset (168 vs 225 bpm), and increased magnitude (20 vs 11 ms) than controls.
Why the study?
Do action potential duration restitution and alternans properties differ between patients with and without structural heart disease?
Population
36 patients, comprising 24 with structural heart disease (SHD) and 12 without SHD.
Comparison
Electrophysiological evaluation. vs Patients without structural heart disease.
Design
Cross-sectional
Authors
Loading...
May signal heightened electrical instability in structural heart disease; leaves open causal role pending prospective validation.
Observational (n=36)
Do action potential duration restitution and alternans properties differ between patients with and without structural heart disease?
Absolute Event Rate: 68% vs 12%
Patients with structural heart disease exhibit altered action potential duration restitution and alternans dynamics, which may contribute to increased cardiac electrical instability.
Koller et al. (2005) conducted an observational in Structural heart disease (n=36). Structural heart disease vs. No structural heart disease was evaluated on Diastolic interval range over which APD alternans was present (ms). Patients with structural heart disease exhibited a wider diastolic interval range for APD alternans (68 vs 12 ms), earlier onset (168 vs 225 bpm), and increased magnitude (20 vs 11 ms) than controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: