Key result
Passive mechanical containment with the Acorn Cardiac Support Device in dogs with heart failure improved cardiomyocyte contraction, downregulated stretch response proteins, and attenuated hypertrophy.
Why the study?
Does passive mechanical ventricular containment with the Acorn Cardiac Support Device reverse molecular and cellular abnormalities in a canine model of heart failure?
Does passive mechanical ventricular containment with the Acorn Cardiac Support Device reverse molecular and cellular abnormalities in a canine model of heart failure?
Passive mechanical containment of the failing left ventricle with the Acorn CSD reverses chronic molecular and cellular abnormalities, including stretch response protein expression and myocyte hypertrophy, in a canine model of heart failure.
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Does not support clinical use; leaves open whether passive containment reverses remodeling in patients.
Sabbah et al. (2003) studied Heart failure (n=18). Acorn Cardiac Support Device (CSD) vs. Untreated heart failure controls and normal dogs was evaluated on Expression of cardiac stretch response proteins, myocyte hypertrophy, SERCA2a activity, and MHC mRNA gene expression. Passive mechanical containment with the Acorn Cardiac Support Device in dogs with heart failure improved cardiomyocyte contraction, downregulated stretch response proteins, and attenuated hypertrophy.
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