Why the study?
Does cardiac contractility modulation therapy normalize the expression of calcium-binding proteins in dogs with heart failure?
Population
20 dogs (7 heart failure dogs treated with CCM, 7 untreated heart failure dogs, 6 normal dogs)
Comparison
Cardiac contractility modulation electrical… vs Untreated heart failure dogs and normal dogs
Design
Preclinical
Authors
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Supports mechanistic exploration of CCM in experimental HF; leaves open clinical relevance of normalized calcium-binding proteins.
Does cardiac contractility modulation therapy normalize the expression of calcium-binding proteins in dogs with heart failure?
CCM therapy restores the expression of key calcium-binding proteins in the failing heart, which may partly explain its mechanism for improving LV function.
Gupta et al. (2009) studied this question.
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