Key result
Myoblast injection demonstrates persisting myotubes 16 years later in an explanted infarcted heart.
Why the study?
Do myoblasts survive long-term when injected into a human infarcted heart?
Case Report (n=1)
Do myoblasts survive long-term when injected into a human infarcted heart?
This case demonstrates that myoblasts can survive for at least 16 years in a human infarcted heart, highlighting their potential for cell-based therapies.
Single-case evidence of durable engraftment; leaves open translation to clinical benefit pending randomized data.
We report the case of a patient who had undergone injections of myoblasts in an infarct area 16 years before being referred for heart transplantation. The pathological examination of the explanted heart found persisting myotubes embedded in fibrosis. This finding supports the ability of myoblasts to survive in harsh environments, which can make them appealing candidates for transplantation in diseases requiring supply of new myogenic cells. Stem Cells Translational Medicine 2018;7:705-708.
No takes yet. Share an insight, caveat, or question.
Crahès et al. (2018) conducted a case report in Infarcted heart (n=1). Myoblast injections was evaluated on Pathological examination of the explanted heart. Pathological examination of an explanted heart 16 years after myoblast injection into an infarct area revealed persisting myotubes embedded in fibrosis, demonstrating long-term survival.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: