Why the study?
Does treatment with CuZn-superoxide dismutase improve graft survival and reduce inflammation after myoblast transplantation to the heart in a mouse model?
Population
Female mice receiving [14C]thymidine-labeled male myoblasts implanted into the myocardium
Comparison
Treatment with CuZn-superoxide dismutase vs Nontreatment
Design
Preclinical
Follow-up
72 hours
Authors
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CuZn-SOD may boost early myoblast survival in mice; leaves open translation to human cardiac cell therapy.
Does treatment with CuZn-superoxide dismutase improve graft survival and reduce inflammation after myoblast transplantation to the heart in a mouse model?
Initial oxidative stress and the subsequent inflammatory response are key mediators of acute graft attrition after myoblast transplantation, and targeting these with CuZn-superoxide dismutase improves cell survival.
Suzuki et al. (2004) studied this question.
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