Key result
Higher aggregate systemic inflammation index independently predicts AVS development in hypertensive patients.
Why the study?
The study investigated the relationship between the presence of aortic valve sclerosis and the aggregate index of systemic inflammation in patients with hypertension.
Does the aggregate index of systemic inflammation (AISI) predict the presence of aortic valve sclerosis in patients with long-term hypertension?
Observational (n=377)
Does the aggregate index of systemic inflammation (AISI) predict the presence of aortic valve sclerosis in patients with long-term hypertension?
Answers are grounded in this paper and cite their sources.
A high aggregate index of systemic inflammation (AISI) is independently associated with the presence of aortic valve sclerosis in patients with long-term hypertension, suggesting its potential utility as an early warning biomarker.
Objective:The aim of this study is to investigate the relationship between the presence of aortic valve sclerosis (AVS) and aggregate index of systemic inflammation (AISI), in patients with hypertension (HT). Material and Methods:Patients with HT diagnosis of 10 years or more who applied to the cardiology outpatient clinic between January and June 2024 were included in our study.Patients were divided into two groups as AVS detected (84 patients) and non-AVS detected (293 patients).AISI was calculated with the neutrophil x platelet x monocyte / lymphocyte formula.Results: AISI was found to be statistically higher in the AVS detected group [421 (127-3400) and 141.57(21-2332); p<0.001].Apart from AISI, age, diabetes history, left ventricular wall thickness and mitral valve early diastolic wave were found to be different between the two groups.In multivariate regression analysis, age (p<0.001),left ventricular posterior wall diameter (p=0.012) and AISI (p<0.002) were found to be independent predictors of AVS development. Conclusion:We found that AISI can be used to detect AVS in long-term HT patients.High AISI values in HT patients can be used as an early warning parameter for poor prognosis.
No takes yet. Share an insight, caveat, or question.
Özderya et al. (2024) conducted an observational in Hypertension and Aortic Valve Sclerosis (n=377). Aggregate Index of Systemic Inflammation (AISI) vs. Non-AVS detected was evaluated on Presence of aortic valve sclerosis (AVS) (p=<0.001). The aggregate index of systemic inflammation was significantly higher in hypertensive patients with aortic valve sclerosis (421 vs 141.57; p<0.001) and independently predicted AVS development.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: