Key result
Elderly patients with systo-diastolic (75.2 bursts/100 beats) and isolated systolic hypertension (70.4) had significantly higher muscle sympathetic nerve activity than normotensives (50.8, P<0.01).
Why the study?
Does sympathetic activation and impaired baroreflex control characterize systo-diastolic and systolic hypertension in the elderly compared to normotensive controls?
Population
31 elderly subjects, including 20 untreated essential hypertensives and 11 age-matched normotensive controls.
Comparison
Measurement of muscle sympathetic nerve activity… vs Age-matched normotensive control subjects.
Design
Case-control
Authors
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Sympathetic activation may characterize elderly hypertension regardless of subtype; leaves open baroreflex role and need for interventional trials.
Cross-Sectional (n=31)
Does sympathetic activation and impaired baroreflex control characterize systo-diastolic and systolic hypertension in the elderly compared to normotensive controls?
Absolute Event Rate: 75.2% vs 50.8%
p-value: p=< 0.01
Sympathetic activation is a feature of elderly hypertensives regardless of whether both systolic and diastolic or only systolic blood pressure is increased, and is not accompanied by impaired baroreceptor modulation of sympathetic nerve traffic.
Grassi et al. (2000) conducted a cross-sectional in Systo-diastolic and systolic hypertension (n=31). Baroreceptor stimulation and deactivation (phenylephrine and nitroprusside) vs. Age-matched normotensive control subjects was evaluated on Muscle sympathetic nerve activity (bursts per 100 heart beats) (p=< 0.01). Elderly patients with systo-diastolic (75.2 bursts/100 beats) and isolated systolic hypertension (70.4) had significantly higher muscle sympathetic nerve activity than normotensives (50.8, P<0.01).
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