Key result
Aging 20 years is linked to an ~8 g/m2 increase in LVMI alongside structural and functional remodeling.
Population
1,045 middle-aged hypertensive subjects and age- and gender-matched control subjects without hypertension…
Design
Cohort
Follow-up
more than 20 years
Authors
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LV structural changes with aging require no immediate clinical action; leaves open modifiable factors in future interventional trials.
Cohort (n=1,045)
p-value: p=<0.001
Aging from middle age to senescence over 20 years is associated with significant increases in left ventricular mass index, posterior wall thickness, fractional shortening, and left atrial diameter.
Möttönen et al. (2017) conducted a cohort in Hypertension (n=1,045). Aging (Observational) was evaluated on Change in left ventricular mass index (LVMI) (p=<0.001). Aging over a 20-year follow-up significantly increased left ventricular mass index from 106.5 to 114.6 g/m2 (p<0.001), along with increases in LVPW thickness, fractional shortening, and LAD.
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