Key result
Depression was an independent risk factor for incident heart failure among elderly women (HR 1.96; 95% CI 1.11-3.46; P=0.02), but not among elderly men.
Why the study?
Does depression increase the risk of incident heart failure in elderly individuals?
Cohort (n=2,501)
No
Does depression increase the risk of incident heart failure in elderly individuals?
Effect estimate: HR 1.52 (95% CI 0.94-2.43)
p-value: p=0.09
Depression is an independent risk factor for incident heart failure among elderly women, but not men.
No takes yet. Share an insight, caveat, or question.
Depression may merit consideration in HF risk assessment for elderly women; leaves open causal inference and sex-specific validation in prospective studies.
Williams et al. (2002) conducted a cohort in Depression and risk of heart failure (n=2,501). Depression (CES-D score ≥21) vs. No depression was evaluated on Incidence of heart failure (hospital admission for heart failure or mortality with heart failure as the underlying cause of death) (HR 1.52, 95% CI 0.94-2.43, p=0.09). Depression was an independent risk factor for incident heart failure among elderly women (HR 1.96; 95% CI 1.11-3.46; P=0.02), but not among elderly men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: