Key result
Depression was an independent risk factor for incident heart failure among elderly women (HR 1.96; 95% CI 1.11-3.46; P=0.02), but not among elderly men.
Why the study?
Does depression increase the risk of incident heart failure in elderly individuals?
Population
2,501 community-dwelling individuals aged ≥65 years free of heart failure at baseline.
Comparison
Depression vs No depression (CES-D score <21)
Design
Cohort
Follow-up
14 years
Authors
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Depression may merit consideration in HF risk assessment for elderly women; leaves open causal inference and sex-specific validation in prospective studies.
Cohort (n=2,501)
No
Does depression increase the risk of incident heart failure in elderly individuals?
Effect estimate: HR 1.52 (95% CI 0.94-2.43)
p-value: p=0.09
Depression is an independent risk factor for incident heart failure among elderly women, but not men.
Williams et al. (2002) conducted a cohort in Depression and risk of heart failure (n=2,501). Depression (CES-D score ≥21) vs. No depression was evaluated on Incidence of heart failure (hospital admission for heart failure or mortality with heart failure as the underlying cause of death) (HR 1.52, 95% CI 0.94-2.43, p=0.09). Depression was an independent risk factor for incident heart failure among elderly women (HR 1.96; 95% CI 1.11-3.46; P=0.02), but not among elderly men.
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