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May 11, 2023Journal of Applied BiomedicineOpen Access

SurHyb trial protocol compares surgical CryoMaze alone versus staged hybrid approach for non-paroxysmal AF.

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Why the study?

In patients undergoing concomitant surgical atrial fibrillation treatment, data comparing a sequential hybrid ablation approach to surgical CryoMaze alone are lacking.

Does surgical CryoMaze followed by radiofrequency catheter ablation improve arrhythmia-free survival without class I or III antiarrhythmic drugs compared to surgical CryoMaze alone in patients with non-paroxysmal atrial fibrillation undergoing cardiac surgery?

Population

Patients with non-paroxysmal AF scheduled for CABG or valve repair/replacement

Comparison

Surgical CryoMaze followed by catheter ablation 3 months post-surgery vs surgical CryoMaze alone

Design

Prospective open-label multicentre randomized trial protocol

Key result

The SurHyb trial is a prospective, open-label, multicentre randomized protocol designed to compare surgical CryoMaze alone versus a staged hybrid approach for non-paroxysmal atrial fibrillation.

Authors

ABAlan BulavaAMAleš MokráčekDWDan Wichterle

Discussion

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Overview

This protocol outlines the first randomized study to compare concomitant surgical CryoMaze alone with a staged hybrid approach (surgical CryoMaze followed by catheter ablation) for non-paroxysmal atrial fibrillation.

Study Design

Type

RCT

Blinding

Open-label

Randomization

randomized

Multicenter

Yes

Structured PICO

Does surgical CryoMaze followed by radiofrequency catheter ablation improve arrhythmia-free survival without class I or III antiarrhythmic drugs compared to surgical CryoMaze alone in patients with non-paroxysmal atrial fibrillation undergoing cardiac surgery?

P
Population
Patients with non-paroxysmal atrial fibrillation who were scheduled for coronary artery bypass grafting or valve repair/replacement
I
Intervention
Surgical CryoMaze followed by radiofrequency catheter ablation 3 months post-surgery
C
Comparator
Surgical CryoMaze alone
O
Outcome
Arrhythmia-free survival without class I or III antiarrhythmic drugs, evaluated using implantable cardiac monitorscomposite

This protocol outlines the first randomized study to compare concomitant surgical CryoMaze alone with a staged hybrid approach (surgical CryoMaze followed by catheter ablation) for non-paroxysmal atrial fibrillation.

Cite This Study

Bulava et al. (2023) conducted an RCT in Non-paroxysmal atrial fibrillation. Surgical CryoMaze followed by radiofrequency catheter ablation vs. Surgical CryoMaze alone was evaluated on Arrhythmia-free survival without class I or III antiarrhythmic drugs. The SurHyb trial is a prospective, open-label, multicentre randomized protocol designed to compare surgical CryoMaze alone versus a staged hybrid approach for non-paroxysmal atrial fibrillation.

synapsesocial.com/papers/6a0dea7d1e1a6dfdb4baed28https://doi.org/10.32725/jab.2023.007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequential Hybrid CryoMaze Ablation versus Surgical CryoMaze Alone for the Treatment of Atrial Fibrillation (SurHyb): study protocol for a randomized controlled trial2016 · 3 citations
  2. 2Sequential hybrid ablation vs. surgical CryoMaze alone for treatment of atrial fibrillation: results of multicentre randomized controlled trial2024 · 8 citations
  3. 3Sequential Hybrid Surgical CryoMaze and Transvenous Catheter Ablation of Atrial Fibrillation2015 · 7 citations
  4. 4Evaluation of Early and Intermediate Outcomes of Cryo-MazeProcedure for Atrial Fibrillation2013 · 1 citations
  5. 5Learning what works in surgical cryoablation of atrial fibrillation: results of different application techniques and benefits of prospective follow-up2011 · 12 citations