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October 24, 2016TrialsOpen Access

SurHyb trial tests hybrid CryoMaze plus catheter ablation versus CryoMaze alone for arrhythmia-free survival.

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Why the study?

Does surgical CryoMaze followed by catheter ablation improve arrhythmia-free survival compared to surgical CryoMaze alone in patients with persistent or long-standing persistent atrial fibrillation undergoing cardiac surgery?

Population

260 patients with persistent or long-standing persistent atrial fibrillation and structural heart disease…

Comparison

Surgical CryoMaze followed by radiofrequency… vs Surgical CryoMaze alone.

Design

Other, Randomized to either surgical CryoMaze alone or surgical CryoMaze…

Follow-up

24 months

Key result

Sequential hybrid surgical CryoMaze followed by catheter ablation is being investigated in the SurHyb randomized controlled trial to determine its efficacy compared to surgical CryoMaze alone.

Authors

MEMartin EisenbergerABAlan BulavaJKJosef Kautzner

Discussion

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Overview

Remains unproven for persistent AF; SurHyb RCT will deliver first randomized evidence.

Study Design

Type

RCT (n=260)

Blinding

Single-blind

Randomization

1:1 ratio via computer system

Multicenter

Yes

Structured PICO

Does surgical CryoMaze followed by catheter ablation improve arrhythmia-free survival compared to surgical CryoMaze alone in patients with persistent or long-standing persistent atrial fibrillation undergoing cardiac surgery?

P
Population
260 patients with persistent or long-standing persistent atrial fibrillation and structural heart disease who are undergoing cardiac surgery.
I
Intervention
Surgical CryoMaze followed by radiofrequency catheter ablation 3 months post-surgery (sequential hybrid approach).
C
Comparator
Surgical CryoMaze alone.
O
Outcome
Arrhythmia-free survival without class I or III antiarrhythmic drugs, evaluated using 7-day ECG Holter monitoring at 24 months.

This study protocol outlines the first randomized trial to compare surgical CryoMaze alone with a staged hybrid approach (surgical CryoMaze followed by catheter ablation) for persistent atrial fibrillation.

Cite This Study

Eisenberger et al. (2016) conducted an RCT in Persistent or long-standing persistent atrial fibrillation (n=260). Sequential hybrid surgical CryoMaze followed by catheter ablation vs. Surgical CryoMaze alone was evaluated on Arrhythmia-free survival without class I or III antiarrhythmic drugs at 24 months. Sequential hybrid surgical CryoMaze followed by catheter ablation is being investigated in the SurHyb randomized controlled trial to determine its efficacy compared to surgical CryoMaze alone.

synapsesocial.com/papers/6a0dea7d1e1a6dfdb4baed30https://doi.org/10.1186/s13063-016-1634-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequential hybrid ablation versus surgical CryoMaze alone for treatment of atrial fibrillation (SurHyb Trial): a protocol of the multicentre randomized controlled trial2023 · 4 citations
  2. 2Sequential hybrid ablation vs. surgical CryoMaze alone for treatment of atrial fibrillation: results of multicentre randomized controlled trial2024 · 8 citations
  3. 3Sequential Hybrid Surgical CryoMaze and Transvenous Catheter Ablation of Atrial Fibrillation2015 · 7 citations
  4. 4Evaluation of Early and Intermediate Outcomes of Cryo-MazeProcedure for Atrial Fibrillation2013 · 1 citations
  5. 5The CryoMaze procedure for non-paroxysmal atrial fibrillation in patients undergoing heart valve surgery2025