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July 14, 2015Pacing and Clinical Electrophysiology

Sequential surgical CryoMaze followed by catheter ablation achieved an 86% arrhythmia-free survival rate off antiarrhythmic drugs at 12 months in patients with persistent atrial fibrillation.

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Why the study?

Does a sequential hybrid approach of surgical CryoMaze followed by RF catheter ablation improve freedom from atrial arrhythmias in patients with persistent atrial fibrillation?

Population

35 patients with persistent atrial fibrillation undergoing a CryoMaze procedure in conjunction with cardiac…

Design

Case_series

Follow-up

12 months after catheter ablation

Key result

Sequential surgical CryoMaze followed by catheter ablation achieved an 86% arrhythmia-free survival rate off antiarrhythmic drugs at 12 months in patients with persistent atrial fibrillation.

Authors

MEMartin EisenbergerABAlan BulavaAMALES MOKRACEK

Discussion

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Overview

Does not support routine hybrid ablation use in persistent AF; leaves open efficacy in randomized trials.

Key Points

  • This study aims to assess the effectiveness of a sequential hybrid approach using CryoMaze and RF catheter ablation in reducing atrial arrhythmias.
  • Thirty-five patients with persistent atrial fibrillation underwent CryoMaze during cardiac surgery.
  • All patients had a 7-day Holter monitoring followed by electrophysiological mapping three months post-surgery.
  • Reisolation of pulmonary veins was performed as necessary with RF energy during the electrophysiological study.
  • At 12 months, the arrhythmia-free survival rate was 86% after RF catheter ablation.
  • Before mapping, 26% of patients had ongoing atrial fibrillation or atrial tachycardia.
  • Complete cryoablation lines around pulmonary veins were found in 83% of patients.

Study Design

Type

Cohort (n=35)

Structured PICO

Does a sequential hybrid approach of surgical CryoMaze followed by RF catheter ablation improve freedom from atrial arrhythmias in patients with persistent atrial fibrillation?

P
Population
35 patients with persistent atrial fibrillation and structural heart disease treated with sequential CryoMaze and catheter ablation, followed for 12 months.
E
Exposure
Sequential hybrid approach: surgical CryoMaze followed 3 months later by electrophysiological study and radiofrequency (RF) catheter ablation to reisolate pulmonary veins and complete ablation lines.
O
Outcome
Arrhythmia-free survival rate off antiarrhythmic drugs at 12 months after catheter ablation.hard clinical

Sequential surgical CryoMaze followed by RF catheter ablation addresses frequently incomplete surgical ablation lines and achieves high rates of arrhythmia-free survival in patients with persistent atrial fibrillation.

Cite This Study

Eisenberger et al. (2015) conducted a cohort in Persistent atrial fibrillation (n=35). Sequential hybrid surgical CryoMaze and transvenous catheter ablation was evaluated on Arrhythmia-free survival rate off antiarrhythmic drugs at 12 months. Sequential surgical CryoMaze followed by catheter ablation achieved an 86% arrhythmia-free survival rate off antiarrhythmic drugs at 12 months in patients with persistent atrial fibrillation.

synapsesocial.com/papers/6a1f45d7d09bc027e483423chttps://doi.org/10.1111/pace.12686
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequential hybrid ablation versus surgical CryoMaze alone for treatment of atrial fibrillation (SurHyb Trial): a protocol of the multicentre randomized controlled trial2023 · 4 citations
  2. 2Sequential hybrid ablation vs. surgical CryoMaze alone for treatment of atrial fibrillation: results of multicentre randomized controlled trial2024 · 8 citations
  3. 3Sequential Hybrid CryoMaze Ablation versus Surgical CryoMaze Alone for the Treatment of Atrial Fibrillation (SurHyb): study protocol for a randomized controlled trial2016 · 3 citations
  4. 4Electroanatomic mapping of recurrent atrial arrhythmias after surgical cryomaze: insights from a single-center retrospective study2026
  5. 5Evaluation of Early and Intermediate Outcomes of Cryo-MazeProcedure for Atrial Fibrillation2013 · 1 citations